Clinical Case Database / Category: Patient Management

Genitourinary tuberculosis: a rare problem in the UK but one that needs to be suspected in high risk groups

Publication details

Dr Arsalan Wafi, Mr Hussain M Alnajjar, Dr Cathy M Corbishley, Mr Harbinder K Sharma
Foundation Years Journal, volume 8, issue 10, p.28 (123Doc Education, London, November 2014)

Abstract

In developed countries, the knowledge of diagnosing and managing tuberculosis (TB) and how it can affect the genitourinary system, for most junior doctors, is gained solely from textbooks. Although this should be hailed as a success story, the surge in intercontinental travel over the past decades highlights the importance of having knowledge of a disease with a global incidence of 8-10 million per year.
Genitourinary tuberculosis (GUTB) is very rare in the UK and very few junior doctors would routinely think about it when managing urological problems. If left untreated, GUTB poses a great risk for public health as well as the patient. Catching it early and ensuring therapy adherence reduces the need for radical surgery and prevents the rise of multidrug-resistant strains. This review article aims to educate junior doctors on the pathophysiology, clinical manifestation, diagnosis and management of GUTB.

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Authors

Dr Arsalan Wafi

Foundation Year 1 Trainee, Bedford Hospital NHS Trust,
South Wing, Kempston Road, MK42 9DJ, UK
wafiarsalan@gmail.com

Mr Hussain M Alnajjar (Corresponding author)

Specialty Registrar in Urology, Bedford Hospital NHS Trust,
South Wing, Kempston Road, MK42 9DJ, UK
hu55doc@gmail.com

Dr Cathy M Corbishley

Consultant Histopathologist, St George's Healthcare NHS Trust,
Blackshaw Road, SW17 0QT, UK
athy.corbishley@stgeorges.nhs.uk

Mr Harbinder K Sharma

Consultant Urological Surgeon, Bedford Hospital NHS Trust,
South Wing, Kempston Road, MK42 9DJ, UK
harbinder.sharma@bedfordhospital.nhs.uk

References

1. World Health Organization. Global tuberculosis control: WHO report 2010. World Health Organization, 2010.
2. Prapruttam, Duangkamon, et al. "Tuberculosis-The great mimicker." Seminars in Ultrasound, CT and MRI. WB Saunders, 2014, 35(3):195-214.
3. Moore RA. Tuberculosis of the prostate gland. J Urol 1937, 37:372–84.
4. Eastwood, J., Corbishley, C. and Grange, J. (2001). Tuberculosis and the kidney. Journal of the American Society of Nephrology 2001, 12(6):1307-1314.
5. Horsburgh CR. Mycobacterium avium complex infection in the acquired immunodeficiency syndrome. N Engl J Med 1991, 324(19): 1332-1338.
6. Deretic, V. and Fratti, R. Mycobacterium tuberculosis phagosome. Molecular microbiology 1999, 31(6):1603-1609.
7. Angus, B., Yates, M., Conlon, C. and Byren, I. Cutaneous tuberculosis of the penis and sexual transmission of tuberculosis confirmed by molecular typing. Clinical Infectious Diseases 2001, 33(11): 132-134.
8. Chavhan, G., Hira, P., Rathod, K., Zacharia, T., Chawla, A., Badhe, P. and Parmar, H. Female genital tuberculosis: hysterosalpingographic appearances. The British Journal of Radiology 2004, 77(914): 164-9.
9. Kini, P. Congenital tuberculosis associated with maternal asymptomatic endometrial tuberculosis. Annals of Tropical Paediatrics: International Child Health 2002, 22(2):179-181.
10. Simon, H., Weinstein, A., Pasternak, M., Swartz, M. and Kunz, L. Genitourinary tuberculosis: clinical features in a general hospital population. The American journal of medicine 1977, 63(3): 410-420.
11. de Oliveira, J., da Silva Junior, G. and Daher, E. Tuberculosis-associated chronic kidney disease. The American journal of tropical medicine and hygiene 2011, 84(6): 843-844.
12. Teo, E. and Wee, T. Images in Clinical Medicine: Renal Tuberculosis. New England Journal of Medicine 2011, 365(12):e26. Doi 10.1056/NEJMicm1100769.
13. Shapiro, A. L., and V. I. Viter. "[Cystoscopy and endovesical biopsy in renal tuberculosis]." Urol Nefrol (Mosk) 1989 Jan-Feb; (1): 12-5.
14. Tsili, A., Tsampoulas, C., Giannakis, D., Papastefanaki, M., Tsiriopoulos, I., Sofikitis, N. and Efremidis, S. Tuberculous epididymo-orchitis: MRI findings. British Institute of Radiology 2014, 81(966):e166-9.
15. Moreno S, Pacho E, López-Herce JA, Rodríguez-Créixems M, Martín-Scapa C, Bouza E. Mycobacterium tuberculosis visceral abscesses in the acquired immunodeficiency syndrome (AIDS). Annals of Internal Medicine 1988, 109(5):437.
16. Lee, Y., Huang, W., Huang, J., Wang, J., Yu, C., Jiaan, B. and Huang, J. Efficacy of chemotherapy for prostatic tuberculosis—a clinical and histologic follow-up study. Urology 2001, 57(5):872-877.
17. Saleh, M., Khaleel, K. and Alsaadi, L. Comparison between polymerase chain reaction and Ziehl Neelsen stain for detection renal tuberculosis. Int. J. Curr. Microbiol. App. Sci 2014, 3(6):408-414.
18. Riska, P., Jacobs, W., Bloom, B., McKitrick, J. and Chan, J. Specific identification of Mycobacterium tuberculosis with the luciferase reporter mycobacteriophage: use of p-nitro-alpha-acetylamino-beta-hydroxy propiophenone. Journal of Clinical Microbiology 1997, 35(12):3225-3231.
19. Mohan, B., Sharda, N. and Singh, S. Evaluation of the recently reported USP gradient HPLC method for analysis of anti-tuberculosis drugs for its ability to resolve degradation products of rifampicin. Journal of pharmaceutical and biomedical analysis 2003, 31(3):607-612.
20. Figueiredo, A., Lucon, A., Arvellos, A., Ramos, C., Toledo, A., Falci Jr, R., Gomes, C., Recaverren, F., Netto, J. and Srougi, M. A better understanding of urogenital tuberculosis pathophysiology based on radiological findings. European journal of radiology 2010, 76(2):246-257.
21. Das, K., Indudhara, R. and Vaidyanathan, S. Sonographic features of genitourinary tuberculosis. AJR. American journal of roentgenology 1992, 158(2):327-329.
22. Batashova, M. I., et al. "[Significance of ultrasonic examination in the diagnosis of genital tuberculosis in women]." Problemy tuberkuleza 1988, 5: 51-53.
23. Quaia, E. and Stacul, F. Imaging Findings in Renal Tuberculosis on Computed Tomography Urography. European Urological Review 2010, 5(2):69-72.
24. Wang, L., Wong, Y., Chen, C. and Lim, K. Pictorial essay. CT features of genitourinary tuberculosis. Journal of computer assisted tomography 1997, 21(2):254-258.
25. Jung, Y., Kim, J. and Cho, K. Genitourinary tuberculosis: comprehensive cross-sectional imaging. American Journal of Roentgenology 2005, 184(1):143-150.
26. Narayana, A. Overview of renal tuberculosis. Urology 1982, 19(3):231-237.
27. Hemal, A., Gupta, N., Rajeev, T., Kumar, R., Dar, L. and Seth, P. Polymerase chain reaction in clinically suspected genitourinary tuberculosis: comparison with intravenous urography, bladder biopsy, and urine acid fast bacilli culture. Urology 2000, 56(4):570-574.
28. Chung-Delgado, K., Revilla-Montag, A., Guillen-Bravo, S., Velez-Segovia, E., Soria-Montoya, A., Nuñez-Garbin, A., Silva-Caso, W. and Bernabe-Ortiz, A. Factors associated with anti-tuberculosis medication adverse effects: a case-control study in Lima, Peru. PloS one 2011, 6(11):e27610.
29. Trauzzi SJ, Kay CJ, Kaufman DG, Lowe FC. Management of prostatic abscess in patients with human immunodeficiency syndrome. Urology 1994, 43(5):629-33.
30. Pablos-Méndez A, Knirsch CA, Barr GR, Lerner BH, Frieden TR. Nonadherence in tuberculosis treatment: predictors and consequences in New York City. The American journal of medicine 1997, 102(2):164-170.

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