Clinical Case Database / Category: Patient Management
Hemolytic uremic syndrome (HUS) in children
Dr Michael O Ogundele MB, BS, MSc, DTCH, MRCPCH, Hani F Ayyash MB, BS, MSc, PhD, FRCPCH
Foundation Years Journal, volume 4, issue 10, p.34 (123Doc Education, London, January 2011)
This case-based discussion is based on an 8-year-old girl who presented with haemolytic uraemic syndrome (HUS) characterised by the triad of thrombocytopenia, micro-angiopathic hemolytic anaemia and acute renal failure, following a diarrhoeal illness caused by escherichia coli O157:H7. The case will highlight relevant aspects of clinical history, physical examination, laboratory investigations, pathophysiology, complications, prognosis, disease notification, management and follow-up of children presenting with HUS. The most common cause of HUS is systemic uptake of toxins in 5â€“10% of individuals infected by Shiga-like toxin-producing E. coli (STEC). Other infective agents such as pneumococci and HIV, complement genetic abnormalities, medications, transplantation, malignancy or autoimmune diseases are responsible for 10% of cases of HUS, referred to as atypical or D-HUS.
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Dr Michael O Ogundele MB, BS, MSc, DTCH, MRCPCH
Dept of Community Paediatrics
Alder Hey Childrens' Hospital NHS Foundation Trust
Liverpool L12 2AP
Hani F Ayyash MB, BS, MSc, PhD, FRCPCH
Dept of Paediatrics
Doncaster and Bassetlaw NHS Foundation Trust
Doncaster DN2 5LT
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