Clinical Case Database / Category: Patient Management

Hyoscine-N-Butyl Bromide (Buscopan) Causing Uterine Hypercontractility Following An Abruption

Publication details

Mr David D’Souza, MB, ChB (Birm), MRCOG, Dr Oliver Meller-Herbert, BSc(Hons), MSc, MB ChB, Victoria Hough, BSc (hons), MSc, PhD, MBChB, DRCOG
Foundation Years Journal, volume 8, issue 7, p.12 (123Doc Education, London, July 2014)

Abstract

Uterine hyperstimulation is a potentially serious complication of labour induction, but may also occur as a side-effect of other medications not used for this purpose. We present a case of uterine hyperstimulation as a proposed consequence of Hyoscine-N-Butyl Bromide (Buscopan) use for ureteric colic in a 32-year-old pregnant patient.

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Authors

Mr David D’Souza, MB, ChB (Birm), MRCOG

Consultant and Honorary Associate Professor of Obstetrics & Gynaecology,
South Warwickshire Foundation Trust,
Lakin Road, Warwick, CV34 5BW
david.d'souza@swft.nhs.uk

Dr Oliver Meller-Herbert, BSc(Hons), MSc, MB ChB

Foundation Year 1 Doctor,
Barking, Havering & Redbridge University Hospitals
ollymel@yahoo.com

Victoria Hough, BSc (hons), MSc, PhD, MBChB, DRCOG

GP Registrar, City Walls Medical Centre, St Martins Way, Chester, CH1 2NR
victoriahough@nhs.net

References

1. Tytgat GN. Hyoscine butylbromide - a review on its parenteral use in acute abdominal spasm and as an aid in abdominal diagnostic and therapeutic procedures. Curr Med Res Opin 2008, 24(11): 3159-73.
2. Tytgat GN. Hyoscine butylbromide: a review of its use in the treatment of abdominal cramping and pain. Drugs 2007, 67(9): 1343-57.
3. Mueller-Lissner S, Tytgat GN, Paulo LG, et al. Placebo- and paracetamol-controlled study on the efficacy and tolerability of hyoscine butylbromide in the treatment of patients with recurrent crampy abdominal pain. Aliment Pharmacol Ther 2006, 23(12): 1741-8.
4. Baracho HMK & Kunalhekar JL. Buscopan in acceleration of labor. J Obstet Gynecol Ind 1984, 35: 509-512.
5. Qahtani NH & Hajeri FA. The effect of hyoscine butylbromide in shortening the first stage of labor: A double blind, randomized, controlled, clinical trial. Ther Clin Risk Manag 2011, 7: 495-500.
6. Samuels LA, Christie L, Roberts-Gittens B, Fletcher H, Frederick J. The effect of hyoscine butylbromide on the first stage of labour in term pregnancies. BJOG 2007, 114(12): 1542-6.

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T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

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