Clinical Case Database / Category: Clinical Care

Immunosuppression in renal transplantation

Publication details

Muhammad Jameel, Laszlo Szabo, Rafael Chavez
Foundation Years Journal, volume 6, issue 7, p.6 (123Doc Education, London, July 2012)


Kidney transplant is the best available treatment for end-stage renal disease. It leads to improved quality of life, prolonged survival and is cost effective compared to dialysis. Despite the above advantages it is related to significant morbidity and mortality due to opportunistic infection and other complications as a consequence of immunosuppression. Here we discuss three renal transplant cases that illustrate some of these complications.

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Muhammad Jameel

Specialist Registrar in Transplant Surgery
Cardiff Transplant Unit
University Hospital Wales
Heath Park, Cardiff
CF14 4XW

Laszlo Szabo

Clinical Fellow in Transplantation
Cardiff Transplant Unit
University Hospital Wales
Heath Park, Cardiff
CF14 4XW

Rafael Chavez (Corresponding author)

Consultant General & Transplant Surgeon
Cardiff Transplant Unit
University Hospital Wales
Heath Park, Cardiff
CF14 4XW

Phone: 02920 746647
Fax: 02920 746661


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3. Calne RY, Alexandre GP, Murray JE. A study of the effects of drugs in prolonged survival of homologous renal transplantation in dogs. Ann N Y Acad Sci. 1962;99:743-761.
4. Starzl TE, Marchioro TL, Waddell WR. The reversal of rejection in human renal homografts with subsequent development of homograft tolerance. Surg Gynecol Obstet. 1963;117:385-395.
5. Veroux M, Giuffrida G, Corona D, et al. Infective complications in renal allograft recipients: epidemiology and outcome. Transplant Proc. 2008;40:1873-1876.
6. Charfeddine K, Zaghden S, Kharrat M, et al. Infectious complications in kidney transplant recipients: a single-center experience. Transplant Proc. 2005;37:2823-2825.
7. Fishman J, Rubin R. Infection in organ-transplant recipients. N Engl J Med. 1998;338:1741-1750.


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