Clinical Case Database / Category: Patient Management

Investigation and management of chronic hepatitis C virus infection

Publication details

Elspeth Bird BSc MBBS, Shahid A Khan BSc MBBS PhD FRC P (Lond), Matthew L Cowan BSc MRC P
Foundation Years Journal, volume 5, issue 8, p.1 (123Doc Education, London, September 2011)


Chronic infection with the hepatitis C virus (HCV) is a major and increasing health problem affecting approximately 185,000 people in the UK in 2009. Longstanding hepatic inflammation can lead to progressive fibrosis that may result in cirrhosis, decompensated liver disease and/or hepatocellular carcinoma. Effective antiviral treatment exists which can cure over 50% of patients. This case-based discussion will focus on the presentation, clinical findings, key investigations and management of a 56 year-old lady with newly diagnosed chronic HCV.

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Elspeth Bird BSc MBBS

Specialist Trainee 1 Imperial College London Liver Unit,
St Mary's Hospital Campus

Shahid A Khan BSc MBBS PhD FRC P (Lond)

Consultant Hepatologist and Clinical Senior Lecturer
Imperial College London Liver Unit, St Mary's Hospital Campus

Matthew L Cowan BSc MRC P

Consultant Hepatologist Imperial College London Liver Unit, St Mary's Hospital Campus


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Conflict Of Interest

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All pictures and investigations shown in this article are shown with the patients’ consent. We require Authors to maintain patients’ anonymity and to obtain consent to report investigations and pictures involving human subjects when anonymity may be compromised. The Journal follows the Guidelines of the Uniform Requirements for Manuscripts ( The Journal requires in its Guidelines for Authors a statement from Authors that “the subject gave informed consent”.

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About the Clinical Cases Database

T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

The database is fully searchable, or can be browsed by medical specialty. Abstracts can be read free of charge, however a subscription is required in order to read the complete cases.