Clinical Case Database / Category: Patient Management

Management of osteoporosis

Publication details

Ali S M Jawad MSc, FRCP, Malvika Gulati MRCP (UK)
Foundation Years Journal, volume 9, issue 10, p.32 (123Doc Education, London, November 2015)

Abstract

Osteoporosis is a common disorder with high morbidity and mortality. It is clinically silent until the first fracture. Treatment is often started late and then inadequately reviewed. Foundation doctors will find this article helpful when managing elderly patients presenting with fractures and falls and when making decisions about primary prevention in General Practice.

Access the Clinical Cases Database

A subscription is required to read the full article. Please subscribe using one of the options below.

ProductPriceSubscription
Foundation Years Clinical Cases Database£29.006 months
Add to cart
Foundation Years Clinical Cases Database£39.0012 months
Add to cart

Authors

Ali S M Jawad MSc, FRCP

Rheumatology Consultant
The Royal London Hospital (Barts Health NHS Trust)
E1 4DG
ali.jawad@bartshealth.nhs.uk

Malvika Gulati MRCP (UK) (Corresponding author)

Rheumatology Registrar
The Royal London Hospital (Barts Health NHS Trust)
E1 4DG
malvika.gulati@nhs.net

References

1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. JAMA 2001, 285:785-95
2. Keene GS, Parker MJ, Pryor GA. Mortality and morbidity after hip fractures. BMJ 1993, 307:1248.
3. Cauley JA. Public health impact of osteoporosis. J Gerontol A Biol Sci Med Sci 2013, 68(10):1243-51
4. Hernlund E, Svedbom A, Ivergard M, et al. Osteoporosis in the European Union: Medical Management, Epidemiology and Economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos 2013; 8:136
5. Lindsay R, Silverman SL, Cooper C et al. Risk of New Vertebral Fracture in the Year Following a fracture. JAMA 2001, 285:320-323
6. Gourlay ML, Fine J, Preisser J et al. Bone-density testing interval and transition to osteoporosis in older women. N Engl J Med 2012, 366:225-233
7. Cummings SR, Karpf DB, Harris F et al. Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs. Am J Med 2002, 112(4):281-9
8. Grey A, Bolland. Web of industry,advocacy, and academia in the management of osteoporosis. BMJ 2015; 351: h3170
9. Cummings S, Black D, Thompson D et al. Effect of Alendronate on Risk of Fracture in Women With Low Bone Density but Without Vertebral Fractures: Results From the Fracture Intervention Trial. JAMA 1998, 280(24):2077-2082
10. Reginster J, Minne HW, Sorensen OH et al. Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group. Osteoporos Int. 2000, 11(1):83-91
11. Colón-Emeric C, Caminis J, Suh T et al. The HORIZON Recurrent Fracture Trial: design of a clinical trial in the prevention of subsequent fractures after low trauma hip fracture repair. Curr Med Res Opin 2004, 20(6):903-10
12. Neer RM, Arnaud CD, Zanchetta JR et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.N Engl J Med. 2001;344(19):1434.
13. Seeman E, Crans GG, Diez-Perez A et al. Anti-vertebral fracture efficacy of raloxifene: a meta-analysis. Osteoporos Int. 2006,17(2):313.
14. Adomaityte J., Farooq M., Qayyum R. Effect of raloxifene therapy on venous thromboembolism in postmenopausal women. A meta-analysis. Thrombosis Haemostasis 2008, 99: 338–342
15. McClung MR, Grauer A, Boonen S et al. Romosozumab in Postmenopausal Women with Low Bone Mineral Density. N Engl J Med 2014, 370:412-420
16. Langdahl B, Binkley N, Bone H et al. Odanacatib in the treatment of postmenopausal women with low bone mineral density: five years of continued therapy in a phase 2 study. J Bone Miner Res. 2012, 27(11):2251
17. Jarvinen T, Michaelsson K, Jokihaara J et al. Overdiagnosis of bone fragility in the quest to prevent hip fracture. BMJ 2015, 350:h2088
18. Stone K, Seeley D Lui L et al. BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res 2003, 18:1947-1954

Disclaimers

Conflict Of Interest

The Journal requires that authors disclose any potential conflict of interest that they may have. This is clearly stated in the Journal’s published “Guidelines for Authors”. The Journal follows the Guidelines against Conflict of Interest published in the Uniform Requirements for Manuscripts Submitted to Biomedical Journals (http://www.icmje.org/urm_full.pdf).

Financial Statement

The authors of this article have not been paid. The Journal is financed by subscriptions and advertising. The Journal does not receive money from any other sources. The decision to accept or refuse this article for publication was free from financial considerations and was solely the responsibility of the Editorial Panel and Editor-in-Chief.

Patient Consent statement

All pictures and investigations shown in this article are shown with the patients’ consent. We require Authors to maintain patients’ anonymity and to obtain consent to report investigations and pictures involving human subjects when anonymity may be compromised. The Journal follows the Guidelines of the Uniform Requirements for Manuscripts (http://www.icmje.org/urm_full.pdf). The Journal requires in its Guidelines for Authors a statement from Authors that “the subject gave informed consent”.

Animal & Human Rights

When reporting experiments on human subjects, the Journal requires authors to indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the HelsinkiDeclaration of 1975, as revised in 2008.

About the Clinical Cases Database

T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

The database is fully searchable, or can be browsed by medical specialty. Abstracts can be read free of charge, however a subscription is required in order to read the complete cases.