Clinical Case Database / Category: Case Based Discussion

Paraneoplastic syndromes

Publication details

Kiruthikah Thillai, Justin Waters
Foundation Years Journal, volume 6, issue 9, p.18 (123Doc Education, London, October 2012)


Paraneoplastic syndromes encompass a heterogeneous group of rare disorders which exist as an indirect consequence of a primary tumour and its metastases. In some cases the syndrome may precede the diagnosis of cancer and an early and accurate recognition of the syndrome is therefore paramount. A case of the neurological paraneoplastic condition ‘Lambert Eaton Myasthenic Syndrome’ is presented here along with a discussion of the relevant investigations and subsequent management.

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Kiruthikah Thillai

Specialist Registrar in Medical Oncology
Kent Oncology Centre,
Maidstone Hospital,
Hermitage Lane, Maidstone,
Kent, ME16 9QQ

Justin Waters

Consultant in Medical Oncology
Kent Oncology Centre,
Maidstone Hospital,
Hermitage Lane, Maidstone,
Kent, ME16 9QQ


1. Rinke A, Müller HH, Schade-Brittinger C, Klose KJ, Barth P, Wied M, Mayer C, Aminossadati B, Pape UF, Bläker M, Harder J, Arnold C, Gress T, Arnold R. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol, 27: 4656-4663 (2009)
2. O’Neill JH, Murray NM, Newsom-Davis J. The Lambert-Eaton myasthenic syndrome. A review of 50 cases. Brain : a journal of neurology, 111 ( Pt 3), 577-596 (1988).
3. Wirtz PW, Smallegange TM, Wintzen AR, Verschuuren JJ. Differences in clinical features between the Lambert-Eaton myasthenic syndrome with and without cancer: an analysis of 227 published cases. Clinical neurology and neurosurgery, 104(4), 359-363 (2002).
4. Rosenfeld MR, Eichen JG, Wade DF, Posner JB, Dalmau J. Molecular and clinical diversity in paraneoplastic immunity to Ma proteins. Annals of neurology, 50(3), 339-348 (2001).
5. Dalmau J. Paraneoplastic disorders of the nervous system. Rinsho shinkeigaku = Clinical neurology, 48(11), 799-803 (2008).
6. Dalmau J, Gultekin HS, Posner JB. Paraneoplastic neurologic syndromes: pathogenesis and physiopathology. Brain Pathol, 9(2), 275-284 (1999).
7. Darnell RB, Posner JB. Paraneoplastic syndromes involving the nervous system. The New England journal of medicine, 349(16), 1543-1554 (2003).


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T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

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