Clinical Case Database / Category: Patient Management

Relapsing clostridium difficile infection and the curative role of faecal transplant

Publication details

Dr Chinenye Ilozue
Foundation Years Journal, volume 9, issue 5, p.42 (123Doc Education, London, May 2015)


This case-based discussion focuses on an elderly patient with multiple comorbidities who had over seven months of relapsing Clostridium difficile infection with diarrhoea. Treatment with all available pharmacological options including intravenous immunoglobulin therapy was unsuccessful. He received a faecal transplant via nasogastric tube to achieve cure after failure of all previous interventions. The case demonstrates the refractory nature of C. difficile infection in high risk populations and presents the important and perhaps underutilised role of faecal transplantation as a relatively low-cost curative intervention. The case highlights the importance of appropriate and targeted antibiotic use in clinical practice considering the high morbidity and mortality associated with severe C. difficile infection.

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Dr Chinenye Ilozue (Corresponding author)

ST3 Infectious Diseases & General Internal Medicine
South Tees Hospitals NHS Foundation Trust
Friarage Hospital, Northallerton, DL6 1JG


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About the Clinical Cases Database

T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

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