Clinical Case Database / Category: Patient Management

Sepsis In Obstetrics

Publication details

Mr N Venkat Raman, Dr MA Shiraz, Dr DD Boban
Foundation Years Journal, volume 8, issue 9, p.72 (123Doc Education, London, October 2014)


In modern day medicine, sepsis is still a major cause of morbidity and mortality; mortality rate from septic shock being as high as 30-70% (1). Confidential enquiries into maternal deaths (CEMACE) in the United Kingdom found sepsis as the leading cause of direct maternal deaths with a dramatic increase in maternal deaths attributable to group A beta-haemolytic streptococci (GAS) (2). Failure of early recognition of signs of sepsis and delayed treatment were important factors identified. Current strategies of early detection and management of sepsis are highlighted in this review.

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Mr N Venkat Raman

Consultant in Obstetrics and Gynaecology
Department of Obstetrics and Gynaecology
Southend University Hospitals NHS Foundation Trust
Prittlewell Chase, Westcliff on Sea, Essex, SS0 0RY

Dr MA Shiraz

Specialist Trainee 1 in Obstetrics and Gynaecology
Department of Obstetrics and Gynaecology
Southend University Hospitals NHS Foundation Trust
Prittlewell Chase, Westcliff on Sea, Essex, SS0 0RY

Dr DD Boban

Locum Consultant in Obstetrics and Gynaecology
Department of Obstetrics and Gynaecology
Wexham Park Hospital, Wexham
Slough, Berkshire, SL2 4HL


1. Russel, J. A. "The current management of septic shock." Minerva medica 99.5 (2008): 431-458.
2. Centre for Maternal and Child Enquiries (CMACE). Saving Mothers' Lives: reviewing maternal deaths to make motherhood safer: 2006â€"08. The Eighth Report on Confidential Enquiries into Maternal Deaths in the United Kingdom. BJOG 2011;118 (Suppl. 1):1â€"203
3. Levy, Mitchell M., et al. "2001 sccm/esicm/accp/ats/sis international sepsis definitions conference." Intensive care medicine 29.4 (2003): 530-538.
4. ACCP / SCCM Consensus Conference Sepsis Definition. Crit Care Med. 1992 Jun; 20(6):864-74
5. Xu, Li, et al. "Progesterone suppresses Th17 cell responses, and enhances the development of regulatory T cells, through thymic stromal lymphopoietin-dependent mechanisms in experimental gonococcal genital tract infection." Microbes and Infection 15.12 (2013): 796-805.
6. Cohen, Jonathan. "The immunopathogenesis of sepsis." Nature 420.6917 (2002): 885-891.
7. Dellinger, R. Phillip, et al. "Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012." Intensive care medicine 39.2 (2013): 165-228.
8. Plaat F,Wray S. Role of the anaesthetist in obstetric critical care. Best Pract Res Clin Obstet Gynaecol 2008; 22: 917â€"35.


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T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

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