Clinical Case Database / Category: Patient Management

Treatment of neutropenic sepsis

Publication details

Anton Borg, MD, FRCP, FRCPath, Stephanie Shayler BSc (Hons), MBChB, MRCP, Jonathan Lancashire BSc (Hons), MBBS, MRCP
Foundation Years Journal, volume 5, issue 7, p.26 (123Doc Education, London, August 2011)


This case based discussion focuses on a 34 year-old female who underwent her second cycle of chemotherapy 10 days ago and now presents with a temperature of 38.5 degrees. The case discusses the assessment, differential diagnosis and treatment of patients who present with neutropenic sepsis.

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Anton Borg, MD, FRCP, FRCPath

Haematology; Aylesford Unit, South Warwickshire
NHS Foundation Trust, Lakin Road, Warwick, CV34 5BW.

Stephanie Shayler BSc (Hons), MBChB, MRCP


Jonathan Lancashire BSc (Hons), MBBS, MRCP



1. Darmon M, Azoulay E, Alberti C, et al. Impact of neutropenia duration on short-term mortality in neutropenic critically ill cancer patients. Intensive Care Medicine 2002;28:1775-80
2. Smith TJ, Khatcheressian J, Lyman GH, et al. 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol 2006; 24:19
3. Taylor, M et al Guidelines for the management of Neutropenic Sepsis, Christie Hospital NHS Foundation Trust. 2008.
4. Hoffbrand, A.V, Moss, P, Pettit, J. Essential Haematology, 5th Edition. Blackwell Publishing 2006. 150-151.


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About the Clinical Cases Database

T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

The database is fully searchable, or can be browsed by medical specialty. Abstracts can be read free of charge, however a subscription is required in order to read the complete cases.