Clinical Case Database / Category: Prescribing

Treatment of status epileticus

Publication details

Thomas J Worrall MBChB, Michael Vassallo PhD FRCP
Foundation Years Journal, volume 2, issue 1, p.37 (123Doc Education, London, January 2008)

Abstract

A 17-year-old man is brought into A&E by ambulance having been fitting for 10 minutes. He does not appear to have a past history of epilepsy. You are a SHO with no senior support immediately to hand. He has already received rectal diazepam (given by the paramedics), and his pulse and blood pressure are currently stable, as is his oxygen saturation.

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Authors

Thomas J Worrall MBChB (Corresponding author)

House Offier
Royal Bournemouth Hospital
Royal Bournemouth Hospital
Castle Lane East
Bournemouth
BH7 7DW

Michael Vassallo PhD FRCP

Consultant Physician and Honorary Senior Clinical Lecturer
Royal Bournemouth Hospital

References

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2. Hesdorffer DC, Logroscino G, Cascino G, Annegers JF, Hausser WA. Incidence of status epilepticus in Rochester, Minnesota, 1965-1984. Neurology 1998;50:735-41
3. Shorvon SD. Tonic-clonic status epilepticus. J Neurol Neurosurg Psychiatry 1993;56:125-34
4. Walker M. Status epilepticus: an evidence based guide. BMJ 2005;331:673- 677
5. NICE. Protocol for treating status epilepticus in adults and children. December, 2003
6. Scottish Intercollegiate Guidelines Network (SIGN). Diagnosis and Management of Epilepsy in Adults: A national clinical guidelines. April, 2003
7. Alldredge BK, Gelb AM, Isaacs SM, Corry MD, Allen F, Ulrich S, et al. A comparison of lorazepam, diazepam, and placebo for the treatment of outof-hospital status epilepticus N Engl J Med 2001;345:631-7
8. Prasad K, Al-Roomi K, Krishnan P, et al. Anticonvulsant therapy for status epilepticus. Cochrane Database Syst Rev 2005;(4):CD003723.
9. Cereghino JJ, Mitchell WG, Murphy J, Kriel RL, Rosenfeld WE, Trevathan E. Treating repetitive seizures with a rectal diazepam formulation: a randomized study. The North American Diastat Study Group. Neurology 1998;51: 1274-82.
10. Leppik IE, Derivan AT, Homan RW, Walker J, Ramsay RE, Patrick B. Doubleblind study of lorazepam and diazepam in status epilepticus. JAMA 1983;249: 1452-4.
11. Mayer SA, Claassen J, Lokin J, Mendelsohn F, Dennis LJ, Fitzsimmons BF. Refractory status epilepticus: frequency, risk factors, and impact on outcome. Arch Neurol 2002;59: 205-10.
12. Burneo JG, Anandan JV, Barkley GL. A prospective study of the incidence of the purple glove syndrome. Epilepsia 2001;42: 1156-9.

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About the Clinical Cases Database

T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

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