Clinical Case Database / Category: Patient Management

Adrenal Masses: The Diagnosis and Management of Conn's Syndrome

Publication details

K Kanesalingam, D van Dellen, T Augustine, JRE Davis
Foundation Years Journal, volume 6, issue 7, p.58 (123Doc Education, London, July 2012)


This case highlights the clinical history and presentation of a young man with hyperaldosteronism. We discuss in detail the aetiology, investigations and treatment options of patients with Conn's syndrome.

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K Kanesalingam

Department of Transplant and Endocrine surgery

D van Dellen

Department of Transplant and Endocrine surgery

T Augustine

Department of Transplant and Endocrine surgery

JRE Davis

Department of Endocrinology
Central Manchester University Hospitals Foundation Trust,
Manchester Royal Infirmary, UK, and Faculty of Medical and Human Sciences,
University of Manchester, UK.


1. Conn JW: Primary aldosteronism: a new clinical syndrome. J LabClin Med 1955, 45:3–17.
2. Rossi GP, Bernini G, Caliumi C, et al.: A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients. J Am Coll Cardiol 2006, 48:2293–2300. This is a large prospective study that was performed to identify the incidence of PA in hypertensive patients.
3. Hiramatsu K, Yamada T, Yukimura Y, et al .A screening test to identify aldosterone producing adenoma by measuring plasma renin activity. Arch. Intern. Med. 1981;141:1589–1593
4. M. Bloomston, O. Al-Saif, D. Klemanski, et al.: Hepatic artery chemo embolization in122 patients with metastatic carcinoid tumor: lessons learned. J Gastrointest Surg. 11,2007, 264, 71.
5. Young WF, Stanson AW: What are the keys to successful adrenal venous sampling (AVS) in patients with primary aldosteronism? Clin Endocrinol 2009, 70:14–17.
6. Rossi HP, Seccia TM, Pessina AC: Primary aldosteronism—part II: subtype differentiation and treatment. J Nephrol 2008, 21:455–462


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About the Clinical Cases Database

T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

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