Clinical Case Database / Category: Case Based Discussion

The investigation of dementia in Down's Syndrome

Publication details

Stephen Tyrer MBBChir MA DPM LMCC FRCPsych
Foundation Years Journal, volume 1, issue 5, p.211 (123Doc Education, London, September 2007)


You are asked to assess a 54 year old man with Down's Syndrome who was admitted to the medical ward following an apparent seizure two days ago. He was witnessed by a carer to be trembling uncontrollably and was unresponsive to commands. He has recently been forgetful and has lost interest in his chosen evening activity of washing-up. He sometimes fails to recognize his older sister when she visits the care home where he has stayed since his mother died 25 years ago.

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Stephen Tyrer MBBChir MA DPM LMCC FRCPsych (Corresponding author)

Consultant/Professor in Psychiatry, Pain and Neurorehabilitation
Royal Victoria Infirmary
Leazes Wing
Royal Victoria Infirmary




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T​he Foundation Years Clinical Cases Database is​ a selection of 600 peer-reviewed clinical cases in the field of patient safety and clinical practice, specifically focused on the clinical information needs of junior doctors, based around the Foundation Year Curriculum programme (MMC). The cases have been chosen to align with the Foundation Year Curriculum.

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